Assay Detail
Binding
CHEMBL3883087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant c-Src using PTK2 substrate incubated for 90 mins by luciferase-based assay
257
Total Activities
257
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzotriazine inhibitors of kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 257 | 7.32 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3639501 | — | — | 1 | 9.27 |
| CHEMBL250821 | — | — | 1 | 9.15 |
| CHEMBL3651288 | — | — | 1 | 9.02 |
| CHEMBL3651286 | — | — | 1 | 9.00 |
| CHEMBL3651285 | — | — | 1 | 8.96 |
| CHEMBL3651262 | — | — | 1 | 8.92 |
| CHEMBL3651292 | — | — | 1 | 8.92 |
| CHEMBL400303 | — | — | 1 | 8.82 |
| CHEMBL3651279 | — | — | 1 | 8.82 |
| CHEMBL400402 | — | — | 1 | 8.80 |
| CHEMBL3651246 | — | — | 1 | 8.80 |
| CHEMBL3651284 | — | — | 1 | 8.80 |
| CHEMBL3651250 | — | — | 1 | 8.74 |
| CHEMBL3651260 | — | — | 1 | 8.74 |
| CHEMBL3651290 | — | — | 1 | 8.68 |
| CHEMBL3651287 | — | — | 1 | 8.62 |
| CHEMBL3651258 | — | — | 1 | 8.59 |
| CHEMBL399246 | — | — | 1 | 8.54 |
| CHEMBL250019 | — | — | 1 | 8.52 |
| CHEMBL249819 | — | — | 1 | 8.52 |
| CHEMBL440963 | — | — | 1 | 8.51 |
| CHEMBL250021 | — | — | 1 | 8.49 |
| CHEMBL3651255 | — | — | 1 | 8.48 |
| CHEMBL3651210 | — | — | 1 | 8.47 |
| CHEMBL3651276 | — | — | 1 | 8.47 |
| CHEMBL249821 | — | — | 1 | 8.44 |
| CHEMBL250214 | — | — | 1 | 8.44 |
| CHEMBL3651295 | — | — | 1 | 8.44 |
| CHEMBL3651283 | — | — | 1 | 8.43 |
| CHEMBL3651291 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3639501 | — | IC50 | = | 0.542 | nM | 9.27 |
| CHEMBL250821 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3651288 | — | IC50 | = | 0.955 | nM | 9.02 |
| CHEMBL3651286 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3651285 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3651292 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3651262 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3651279 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL400303 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3651284 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL400402 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3651246 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3651250 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3651260 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3651290 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3651287 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3651258 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL399246 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL249819 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL250019 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL440963 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL250021 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3651255 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3651210 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3651276 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3651295 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL250214 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL249821 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3651283 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3651291 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL398279 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3651257 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3651253 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3651278 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3651277 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3648050 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL250218 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3651228 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL399268 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3651280 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL250625 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3651231 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3651219 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL218549 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3651212 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL250423 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL250623 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL436137 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL231251 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3651249 | — | IC50 | = | 6.8 | nM | 8.17 |