Assay Detail
Binding
CHEMBL3883090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of active N-terminal His6-tagged human recombinant EphB4 (amino acids 561 to end) using poly(glu4tyr) substrate incubated for 60 mins by luciferase-based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzotriazine inhibitors of kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.14 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL400402 | — | — | 1 | 7.80 |
| CHEMBL249821 | — | — | 1 | 7.51 |
| CHEMBL230686 | — | — | 1 | 7.40 |
| CHEMBL436137 | — | — | 1 | 7.31 |
| CHEMBL268825 | — | — | 1 | 7.24 |
| CHEMBL3648039 | — | — | 1 | 7.18 |
| CHEMBL3648061 | — | — | 1 | 7.18 |
| CHEMBL3648058 | — | — | 1 | 7.16 |
| CHEMBL231218 | — | — | 1 | 7.13 |
| CHEMBL230685 | — | — | 1 | 6.41 |
| CHEMBL3651269 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL400402 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL249821 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL230686 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL436137 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL268825 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3648039 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3648061 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL3648058 | — | IC50 | = | 68.7 | nM | 7.16 |
| CHEMBL231218 | — | IC50 | = | 73.7 | nM | 7.13 |
| CHEMBL230685 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL3651269 | — | IC50 | = | 596.0 | nM | 6.22 |