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Assay Detail

CHEMBL3883093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins
ChEMBL ↗
55
Total Activities
55
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Therapeutic compounds
(2010)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 44 5.89 8.10
IC50 11 5.15 5.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3947001 — — 1 8.10
CHEMBL3977724 — — 1 8.00
CHEMBL3971632 — — 1 7.82
CHEMBL3936540 — — 1 7.60
CHEMBL3920756 — — 1 7.51
CHEMBL3903611 — — 1 7.27
CHEMBL3959653 — — 1 6.96
CHEMBL3892847 — — 1 6.94
CHEMBL3921784 — — 1 6.79
CHEMBL3975238 — — 1 6.41
CHEMBL3959926 — — 1 6.30
CHEMBL3908484 — — 1 6.30
CHEMBL3896693 — — 1 6.22
CHEMBL3950412 — — 1 6.22
CHEMBL3964261 — — 1 6.16
CHEMBL3920796 — — 1 6.16
CHEMBL1722929 — — 1 6.06
CHEMBL3973347 — — 1 5.90
CHEMBL3959769 — — 1 5.86
CHEMBL3943966 — — 1 5.85
CHEMBL3920560 — — 1 5.81
CHEMBL3907809 — — 1 5.79
CHEMBL3896183 — — 1 5.72
CHEMBL3928130 — — 1 5.69
CHEMBL3906402 — — 1 5.64
CHEMBL3956391 — — 1 5.64
CHEMBL3912391 — — 1 5.55
CHEMBL3983069 — — 1 5.44
CHEMBL3891401 — — 1 5.40
CHEMBL3973312 — — 1 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3947001 — Ki = 8.0 nM 8.10
CHEMBL3977724 — Ki = 10.0 nM 8.00
CHEMBL3971632 — Ki = 15.0 nM 7.82
CHEMBL3936540 — Ki = 25.0 nM 7.60
CHEMBL3920756 — Ki = 31.0 nM 7.51
CHEMBL3903611 — Ki = 54.0 nM 7.27
CHEMBL3959653 — Ki = 111.0 nM 6.96
CHEMBL3892847 — Ki = 115.0 nM 6.94
CHEMBL3921784 — Ki = 163.0 nM 6.79
CHEMBL3975238 — Ki = 387.0 nM 6.41
CHEMBL3959926 — Ki = 504.0 nM 6.30
CHEMBL3908484 — Ki = 501.0 nM 6.30
CHEMBL3950412 — Ki = 600.0 nM 6.22
CHEMBL3896693 — Ki = 600.0 nM 6.22
CHEMBL3920796 — Ki = 700.0 nM 6.16
CHEMBL3964261 — Ki = 700.0 nM 6.16
CHEMBL1722929 — Ki = 871.0 nM 6.06
CHEMBL3973347 — Ki = 1252.0 nM 5.90
CHEMBL3959769 — Ki = 1382.0 nM 5.86
CHEMBL3943966 — Ki = 1400.0 nM 5.85
CHEMBL3920560 — IC50 = 1537.0 nM 5.81
CHEMBL3907809 — Ki = 1639.0 nM 5.79
CHEMBL3896183 — Ki = 1900.0 nM 5.72
CHEMBL3928130 — Ki = 2028.0 nM 5.69
CHEMBL3956391 — IC50 = 2281.0 nM 5.64
CHEMBL3906402 — Ki = 2293.0 nM 5.64
CHEMBL3912391 — Ki = 2811.0 nM 5.55
CHEMBL3983069 — IC50 = 3630.0 nM 5.44
CHEMBL3891401 — Ki = 4000.0 nM 5.40
CHEMBL3973312 — IC50 = 4185.0 nM 5.38
CHEMBL3949271 — Ki = 4600.0 nM 5.34
CHEMBL3922151 — Ki = 4677.0 nM 5.33
CHEMBL3986829 — IC50 = 5200.0 nM 5.28
CHEMBL3918349 — Ki = 5731.0 nM 5.24
CHEMBL3976116 — IC50 = 6251.0 nM 5.20
CHEMBL3909989 — Ki = 7100.0 nM 5.15
CHEMBL3922121 — IC50 = 8950.0 nM 5.05
CHEMBL3909111 — IC50 = 13139.0 nM 4.88
CHEMBL3934202 — IC50 = 13150.0 nM 4.88
CHEMBL3918084 — Ki = 15000.0 nM 4.82
CHEMBL3914108 — Ki = 15000.0 nM 4.82
CHEMBL3912658 — Ki = 15000.0 nM 4.82
CHEMBL3919393 — IC50 = 18735.0 nM 4.73
CHEMBL3901873 — Ki = 22726.0 nM 4.64
CHEMBL3971493 — IC50 = 48765.0 nM 4.31
CHEMBL3947785 — Ki = 50000.0 nM 4.30
CHEMBL3961847 — Ki = 50000.0 nM 4.30
CHEMBL3898887 — Ki = 50000.0 nM 4.30
CHEMBL3957958 — Ki = 50000.0 nM 4.30
CHEMBL3911438 — Ki = 50000.0 nM 4.30