Assay Detail
Binding
CHEMBL3887148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Fluorescence Polarization Assays: In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a versatile laboratory technique for measuring equilibrium binding, nucleic acid hybridization, and enzymatic activity. Fluorescence polarization assays are homogeneous in that they do not require a separation step such as centrifugation, filtration, chromatography, precipitation, or electrophoresis. These assays are done in real time, directly in solution and do not require an immobilized phase. Polarization values can be measured repeatedly and after the addition of reagents since measuring the polarization is rapid and does not destroy the sample. Generally, this technique can be used to measure polarization values of fluorophores from low picomolar to micromolar levels.
149
Total Activities
116
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 149 | 5.68 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3895068 | — | — | 1 | 7.85 |
| CHEMBL3909546 | — | — | 1 | 7.44 |
| CHEMBL3907785 | — | — | 1 | 7.27 |
| CHEMBL3930803 | — | — | 1 | 7.08 |
| CHEMBL3905445 | — | — | 1 | 7.04 |
| CHEMBL3904387 | — | — | 1 | 6.96 |
| CHEMBL3901989 | — | — | 1 | 6.73 |
| CHEMBL3092287 | — | — | 2 | 6.70 |
| CHEMBL3946036 | — | — | 1 | 6.62 |
| CHEMBL1401915 | — | — | 1 | 6.58 |
| CHEMBL3962122 | — | — | 1 | 6.54 |
| CHEMBL3917592 | — | — | 1 | 6.48 |
| CHEMBL3972175 | — | — | 1 | 6.47 |
| CHEMBL3954153 | — | — | 2 | 6.46 |
| CHEMBL1082389 | — | — | 1 | 6.41 |
| CHEMBL3892321 | — | — | 2 | 6.39 |
| CHEMBL3907807 | — | — | 2 | 6.37 |
| CHEMBL3976457 | — | — | 1 | 6.34 |
| CHEMBL3982886 | — | — | 1 | 6.30 |
| CHEMBL3908011 | — | — | 1 | 6.30 |
| CHEMBL3894540 | — | — | 1 | 6.23 |
| CHEMBL3978302 | — | — | 1 | 6.17 |
| CHEMBL1356858 | — | — | 1 | 6.17 |
| CHEMBL3945665 | — | — | 1 | 6.15 |
| CHEMBL3965603 | — | — | 1 | 6.15 |
| CHEMBL1499181 | — | — | 1 | 6.14 |
| CHEMBL1711155 | — | — | 1 | 6.12 |
| CHEMBL3976205 | — | — | 1 | 6.08 |
| CHEMBL3953366 | — | — | 1 | 6.07 |
| CHEMBL3916808 | — | — | 2 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3895068 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3909546 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3907785 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3930803 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3905445 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3904387 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3901989 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL3092287 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3092287 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3946036 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1401915 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL3962122 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL3917592 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL3972175 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL3954153 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL3954153 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL1082389 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL3892321 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3892321 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3907807 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3907807 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3976457 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL3982886 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL3908011 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL3894540 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1356858 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL3978302 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL3945665 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL3965603 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1499181 | — | IC50 | = | 721.0 | nM | 6.14 |
| CHEMBL1711155 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL3976205 | — | IC50 | = | 842.0 | nM | 6.08 |
| CHEMBL3953366 | — | IC50 | = | 861.0 | nM | 6.07 |
| CHEMBL1419634 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL3916808 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL3916808 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL1419634 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL1366449 | — | IC50 | = | 1006.0 | nM | 6.00 |
| CHEMBL3983085 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3940903 | — | IC50 | = | 1255.0 | nM | 5.90 |
| CHEMBL3982834 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL3982834 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL3977716 | — | IC50 | = | 1397.0 | nM | 5.86 |
| CHEMBL3977716 | — | IC50 | = | 1397.0 | nM | 5.86 |
| CHEMBL3916784 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3921682 | — | IC50 | = | 1619.0 | nM | 5.79 |
| CHEMBL3946037 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3907800 | — | IC50 | = | 1651.0 | nM | 5.78 |
| CHEMBL3935097 | — | IC50 | = | 1726.0 | nM | 5.76 |
| CHEMBL3935097 | — | IC50 | = | 1726.0 | nM | 5.76 |