Assay Detail
Binding
CHEMBL3888075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biological Assay: The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.
37
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neurogenic locus notch homolog protein 1 (CHEMBL2146346) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.38 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922868 | — | — | 1 | 8.85 |
| CHEMBL3908473 | — | — | 1 | 8.80 |
| CHEMBL3929363 | — | — | 1 | 8.77 |
| CHEMBL3896661 | — | — | 1 | 8.74 |
| CHEMBL3915833 | — | — | 1 | 8.64 |
| CHEMBL3944645 | — | — | 1 | 8.60 |
| CHEMBL3984170 | — | — | 1 | 8.55 |
| CHEMBL3973748 | — | — | 1 | 8.55 |
| CHEMBL3913200 | — | — | 2 | 8.52 |
| CHEMBL3984723 | — | — | 1 | 8.52 |
| CHEMBL3938447 | — | — | 1 | 8.51 |
| CHEMBL3919904 | — | — | 1 | 8.48 |
| CHEMBL3983707 | — | — | 1 | 8.47 |
| CHEMBL3935299 | — | — | 1 | 8.43 |
| CHEMBL3895390 | — | — | 1 | 8.41 |
| CHEMBL3960841 | — | — | 2 | 8.37 |
| CHEMBL3909875 | — | — | 1 | 8.37 |
| CHEMBL3923405 | — | — | 1 | 8.36 |
| CHEMBL3891599 | — | — | 1 | 8.36 |
| CHEMBL3965388 | — | — | 1 | 8.34 |
| CHEMBL3950601 | — | — | 1 | 8.33 |
| CHEMBL3944272 | — | — | 1 | 8.32 |
| CHEMBL3985392 | — | — | 1 | 8.32 |
| CHEMBL3983168 | — | — | 1 | 8.32 |
| CHEMBL3984405 | — | — | 1 | 8.31 |
| CHEMBL3948923 | — | — | 1 | 8.24 |
| CHEMBL3949951 | — | — | 1 | 8.24 |
| CHEMBL3977486 | — | — | 1 | 8.22 |
| CHEMBL3903119 | — | — | 1 | 8.21 |
| CHEMBL3955547 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922868 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3908473 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3929363 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3896661 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3915833 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3944645 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3984170 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3973748 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3913200 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3984723 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3938447 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3919904 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3983707 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3935299 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3895390 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3960841 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3909875 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3891599 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3923405 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3965388 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3950601 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3944272 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3985392 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3983168 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3960841 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3984405 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3949951 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3948923 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3977486 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3903119 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3955547 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3985584 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3965328 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3911164 | VAREGACESTAT | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3913200 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3893305 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3971963 | — | IC50 | = | 12.2 | nM | 7.91 |