Assay Detail
Binding
CHEMBL3888077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biological Assay: The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.
37
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neurogenic locus notch homolog protein 3 (CHEMBL3407319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.30 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3908473 | — | — | 1 | 8.85 |
| CHEMBL3896661 | — | — | 1 | 8.72 |
| CHEMBL3922868 | — | — | 1 | 8.68 |
| CHEMBL3948923 | — | — | 1 | 8.62 |
| CHEMBL3973748 | — | — | 1 | 8.57 |
| CHEMBL3929363 | — | — | 1 | 8.54 |
| CHEMBL3971963 | — | — | 1 | 8.52 |
| CHEMBL3984723 | — | — | 1 | 8.49 |
| CHEMBL3935299 | — | — | 1 | 8.47 |
| CHEMBL3913200 | — | — | 2 | 8.43 |
| CHEMBL3949951 | — | — | 1 | 8.43 |
| CHEMBL3915833 | — | — | 1 | 8.40 |
| CHEMBL3985392 | — | — | 1 | 8.40 |
| CHEMBL3960841 | — | — | 2 | 8.38 |
| CHEMBL3984405 | — | — | 1 | 8.37 |
| CHEMBL3923405 | — | — | 1 | 8.36 |
| CHEMBL3891599 | — | — | 1 | 8.36 |
| CHEMBL3985584 | — | — | 1 | 8.35 |
| CHEMBL3984170 | — | — | 1 | 8.34 |
| CHEMBL3983707 | — | — | 1 | 8.31 |
| CHEMBL3944645 | — | — | 1 | 8.27 |
| CHEMBL3895390 | — | — | 1 | 8.24 |
| CHEMBL3919904 | — | — | 1 | 8.21 |
| CHEMBL3955547 | — | — | 1 | 8.21 |
| CHEMBL3938447 | — | — | 1 | 8.20 |
| CHEMBL3944272 | — | — | 1 | 8.14 |
| CHEMBL3893305 | — | — | 1 | 8.14 |
| CHEMBL3909875 | — | — | 1 | 8.13 |
| CHEMBL3965388 | — | — | 1 | 8.11 |
| CHEMBL3950601 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3908473 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3896661 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3922868 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3948923 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3973748 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3929363 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3971963 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3984723 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3935299 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3949951 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3913200 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3915833 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3985392 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3960841 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3984405 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3923405 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3891599 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3985584 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3984170 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3983707 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3944645 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3895390 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3955547 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3919904 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3938447 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3893305 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3944272 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3909875 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3965388 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3960841 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3950601 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3911164 | VAREGACESTAT | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3903119 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3977486 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL3965328 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL3983168 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL3913200 | — | IC50 | = | 15.0 | nM | 7.82 |