Assay Detail

CHEMBL3992020

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Functional

Cytotoxic activity in human DMS153 cells expressing Rad51

ChEMBL ↗

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Target

DMS-153 (CHEMBL2366167) ↗

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Primary target DMS-153

CHEMBL2366167

Anchored from Assay target.

Protein identity DMS-153

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DMS-153
Confidence	1 — Organism
Curated By	Autocuration

Target

DMS-153 (CHEMBL2366167) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same

(2013)

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.92	6.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL44657	ETOPOSIDE	4.0	1	6.54
CHEMBL2105685	AMUVATINIB HYDROCHLORIDE	-1.0	1	5.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL44657	ETOPOSIDE	IC50	=	290.0	nM	6.54
CHEMBL2105685	AMUVATINIB HYDROCHLORIDE	IC50	=	5140.0	nM	5.29