Assay Detail
Binding
CHEMBL3992389
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Inhibition of DcpS in human SMN2 promoter driven mouse NSC-34 cells assessed as increase in SMN2 mRNA expression after 18 hrs by RT-PCR analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of DCPS
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.74 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251429 | — | — | 1 | 8.40 |
| CHEMBL1232147 | — | — | 1 | 7.17 |
| CHEMBL4076514 | — | — | 1 | 6.98 |
| CHEMBL4086727 | — | — | 1 | 6.97 |
| CHEMBL4078872 | — | — | 1 | 6.65 |
| CHEMBL4096904 | — | — | 1 | 6.10 |
| CHEMBL4105061 | — | — | 1 | 6.04 |
| CHEMBL4090759 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251429 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1232147 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4076514 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4086727 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4078872 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4096904 | — | EC50 | = | 795.0 | nM | 6.10 |
| CHEMBL4105061 | — | EC50 | = | 921.0 | nM | 6.04 |
| CHEMBL4090759 | — | EC50 | = | 2540.0 | nM | 5.59 |