Assay Detail
Binding
CHEMBL3993539
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Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.20 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060841 | — | — | 1 | 9.51 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.35 |
| CHEMBL4069517 | — | — | 1 | 8.98 |
| CHEMBL4075266 | — | — | 1 | 8.87 |
| CHEMBL4089043 | — | — | 1 | 8.85 |
| CHEMBL4100979 | — | — | 1 | 8.85 |
| CHEMBL4104599 | — | — | 1 | 8.25 |
| CHEMBL4072514 | — | — | 1 | 8.11 |
| CHEMBL4066813 | — | — | 1 | 7.94 |
| CHEMBL4063920 | — | — | 1 | 7.49 |
| CHEMBL4088100 | — | — | 1 | 7.48 |
| CHEMBL4086694 | — | — | 1 | 7.46 |
| CHEMBL4092519 | — | — | 1 | 7.45 |
| CHEMBL4083001 | — | — | 1 | 6.16 |
| CHEMBL4085653 | — | — | 1 | - |
| CHEMBL4080224 | — | — | 1 | - |
| CHEMBL4104466 | — | — | 1 | - |
| CHEMBL4103584 | — | — | 1 | - |
| CHEMBL4087541 | — | — | 1 | - |
| CHEMBL4060113 | — | — | 1 | - |
| CHEMBL4082005 | — | — | 1 | - |
| CHEMBL4085495 | — | — | 1 | - |
| CHEMBL4101918 | — | — | 1 | - |
| CHEMBL4093247 | — | — | 1 | - |
| CHEMBL4071731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060841 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4069517 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL4075266 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL4089043 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL4100979 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4104599 | — | IC50 | = | 5.58 | nM | 8.25 |
| CHEMBL4072514 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4066813 | — | IC50 | = | 11.41 | nM | 7.94 |
| CHEMBL4063920 | — | IC50 | = | 32.37 | nM | 7.49 |
| CHEMBL4088100 | — | IC50 | = | 33.02 | nM | 7.48 |
| CHEMBL4086694 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL4092519 | — | IC50 | = | 35.75 | nM | 7.45 |
| CHEMBL4083001 | — | IC50 | = | 700.53 | nM | 6.16 |
| CHEMBL4085653 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4080224 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4104466 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4103584 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4087541 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4060113 | — | IC50 | - | — | - | |
| CHEMBL4082005 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4085495 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4101918 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4093247 | — | IC50 | - | — | - | |
| CHEMBL4071731 | — | IC50 | > | 1000.0 | nM | - |