Assay Detail
Binding
CHEMBL3993915
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Inhibition of human recombinant carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.34 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096684 | — | — | 1 | 8.23 |
| CHEMBL4085952 | — | — | 1 | 8.18 |
| CHEMBL4069845 | — | — | 1 | 8.17 |
| CHEMBL4095939 | — | — | 1 | 8.11 |
| CHEMBL4088398 | — | — | 1 | 8.03 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4077244 | — | — | 1 | 7.75 |
| CHEMBL4103521 | — | — | 1 | 7.54 |
| CHEMBL4067135 | — | — | 1 | 7.47 |
| CHEMBL4096121 | — | — | 1 | 7.46 |
| CHEMBL7087 | — | — | 1 | 7.43 |
| CHEMBL4066127 | — | — | 1 | 7.38 |
| CHEMBL4078069 | — | — | 1 | 7.30 |
| CHEMBL4069467 | — | — | 1 | 7.22 |
| CHEMBL4085590 | — | — | 1 | 7.19 |
| CHEMBL4060777 | — | — | 1 | 6.80 |
| CHEMBL4099138 | — | — | 1 | 6.60 |
| CHEMBL4081098 | — | — | 1 | 6.58 |
| CHEMBL4088987 | — | — | 1 | 6.52 |
| CHEMBL4104409 | — | — | 1 | 6.15 |
| CHEMBL4080175 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096684 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4085952 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4069845 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL4095939 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4088398 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4077244 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL4103521 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL4067135 | — | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL4096121 | — | Ki | = | 34.4 | nM | 7.46 |
| CHEMBL7087 | — | Ki | = | 36.8 | nM | 7.43 |
| CHEMBL4066127 | — | Ki | = | 41.4 | nM | 7.38 |
| CHEMBL4078069 | — | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL4069467 | — | Ki | = | 59.7 | nM | 7.22 |
| CHEMBL4085590 | — | Ki | = | 63.9 | nM | 7.19 |
| CHEMBL4060777 | — | Ki | = | 157.4 | nM | 6.80 |
| CHEMBL4099138 | — | Ki | = | 249.3 | nM | 6.60 |
| CHEMBL4081098 | — | Ki | = | 261.6 | nM | 6.58 |
| CHEMBL4088987 | — | Ki | = | 302.1 | nM | 6.52 |
| CHEMBL4104409 | — | Ki | = | 713.9 | nM | 6.15 |
| CHEMBL4080175 | — | Ki | = | 761.9 | nM | 6.12 |