Assay Detail
Binding
CHEMBL3994284
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Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3A-stimulated beta-catenin response transcription after 6 hrs by TOPflash dual luciferase reporter gene assay
17
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.88 | 6.92 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 2 | 6.92 |
| CHEMBL4063414 | — | — | 2 | 6.64 |
| CHEMBL1944805 | — | — | 2 | 6.44 |
| CHEMBL4102601 | — | — | 2 | 6.21 |
| CHEMBL4061607 | — | — | 1 | 5.90 |
| CHEMBL4087103 | — | — | 1 | 5.82 |
| CHEMBL1944796 | — | — | 1 | 5.81 |
| CHEMBL4097451 | — | — | 1 | 5.77 |
| CHEMBL4091270 | — | — | 1 | 5.57 |
| CHEMBL4096490 | — | — | 1 | 5.50 |
| CHEMBL4083896 | — | — | 1 | 5.38 |
| CHEMBL1944806 | — | — | 1 | 5.35 |
| CHEMBL4093926 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4063414 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1944805 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4102601 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4061607 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4087103 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1944796 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4097451 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4091270 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4096490 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4083896 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL1944806 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4093926 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL1944805 | — | Inhibition | - | % | - | |
| CHEMBL4063414 | — | Inhibition | - | % | - | |
| CHEMBL4102601 | — | Inhibition | - | % | - | |
| CHEMBL1448 | NICLOSAMIDE | Inhibition | - | % | - |