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Assay Detail

CHEMBL3994352

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Luo L, Li Y, Qiang X, Cao Z, Xu R, Yang X, Xiao G, Song Q, Tan Z, Deng Y.
Bioorg Med Chem (2017) 25 : 1997 -2009
PubMed 28237559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.08 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL887 RASAGILINE 4.0 1 8.00
CHEMBL4094880 1 6.57
CHEMBL2018439 1 6.52
CHEMBL4085819 1 6.48
CHEMBL4072860 1 6.46
CHEMBL4093991 1 6.43
CHEMBL4064264 1 6.42
CHEMBL4066985 1 6.41
CHEMBL4077948 1 6.34
CHEMBL4067447 1 6.23
CHEMBL4101300 1 6.06
CHEMBL4102209 1 6.05
CHEMBL92401 IPRONIAZID 2.0 1 6.01
CHEMBL4101723 1 5.76
CHEMBL4064738 1 5.73
CHEMBL4083301 1 5.70
CHEMBL4093565 1 5.66
CHEMBL8706 CLORGILINE 2.0 1 5.61
CHEMBL4073325 1 5.45
CHEMBL4086224 1 5.43
CHEMBL4063688 1 5.21
CHEMBL4091504 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL887 RASAGILINE IC50 = 9.97 nM 8.00
CHEMBL4094880 IC50 = 270.0 nM 6.57
CHEMBL2018439 IC50 = 300.0 nM 6.52
CHEMBL4085819 IC50 = 330.0 nM 6.48
CHEMBL4072860 IC50 = 350.0 nM 6.46
CHEMBL4093991 IC50 = 370.0 nM 6.43
CHEMBL4064264 IC50 = 380.0 nM 6.42
CHEMBL4066985 IC50 = 390.0 nM 6.41
CHEMBL4077948 IC50 = 460.0 nM 6.34
CHEMBL4067447 IC50 = 590.0 nM 6.23
CHEMBL4101300 IC50 = 880.0 nM 6.06
CHEMBL4102209 IC50 = 900.0 nM 6.05
CHEMBL92401 IPRONIAZID IC50 = 985.0 nM 6.01
CHEMBL4101723 IC50 = 1730.0 nM 5.76
CHEMBL4064738 IC50 = 1880.0 nM 5.73
CHEMBL4083301 IC50 = 2020.0 nM 5.70
CHEMBL4093565 IC50 = 2200.0 nM 5.66
CHEMBL8706 CLORGILINE IC50 = 2430.0 nM 5.61
CHEMBL4073325 IC50 = 3550.0 nM 5.45
CHEMBL4086224 IC50 = 3730.0 nM 5.43
CHEMBL4063688 IC50 = 6090.0 nM 5.21
CHEMBL4091504 IC50 = 7130.0 nM 5.15