Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3995437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of curcumin inspired indole analogues as tubulin polymerization inhibitors.
Sri Ramya PV, Angapelly S, Guntuku L, Singh Digwal C, Nagendra Babu B, Naidu VGM, Kamal A.
Eur J Med Chem (2017) 127 : 100 -114
PubMed 28038323 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.63 7.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL501867 VINCRISTINE SULFATE 4.0 1 7.56
CHEMBL4087665 1 5.51
CHEMBL4066311 1 5.50
CHEMBL4093807 1 5.46
CHEMBL4090404 1 5.26
CHEMBL4069366 1 5.20
CHEMBL140 CURCUMIN 3.0 1 4.91
CHEMBL4082493 1 -
CHEMBL4076125 1 -
CHEMBL4100510 1 -
CHEMBL4077065 1 -
CHEMBL4066895 1 -
CHEMBL4061684 1 -
CHEMBL4076871 1 -
CHEMBL4090339 1 -
CHEMBL4075526 1 -
CHEMBL4086926 1 -
CHEMBL4074762 1 -
CHEMBL4101445 1 -
CHEMBL4083478 1 -
CHEMBL4101528 1 -
CHEMBL4091322 1 -
CHEMBL4063464 1 -
CHEMBL4075935 1 -
CHEMBL4086050 1 -
CHEMBL4073113 1 -
CHEMBL4083530 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL501867 VINCRISTINE SULFATE IC50 = 27.6 nM 7.56
CHEMBL4087665 IC50 = 3120.0 nM 5.51
CHEMBL4066311 IC50 = 3150.0 nM 5.50
CHEMBL4093807 IC50 = 3510.0 nM 5.46
CHEMBL4090404 IC50 = 5520.0 nM 5.26
CHEMBL4069366 IC50 = 6340.0 nM 5.20
CHEMBL140 CURCUMIN IC50 = 12220.0 nM 4.91
CHEMBL4082493 IC50 > 50000.0 nM -
CHEMBL4076125 IC50 > 50000.0 nM -
CHEMBL4100510 IC50 > 50000.0 nM -
CHEMBL4077065 IC50 > 50000.0 nM -
CHEMBL4066895 IC50 > 50000.0 nM -
CHEMBL4061684 IC50 > 50000.0 nM -
CHEMBL4076871 IC50 > 50000.0 nM -
CHEMBL4090339 IC50 > 50000.0 nM -
CHEMBL4075526 IC50 > 50000.0 nM -
CHEMBL4086926 IC50 > 50000.0 nM -
CHEMBL4074762 IC50 > 50000.0 nM -
CHEMBL4101445 IC50 > 50000.0 nM -
CHEMBL4083478 IC50 > 50000.0 nM -
CHEMBL4101528 IC50 > 50000.0 nM -
CHEMBL4091322 IC50 > 50000.0 nM -
CHEMBL4063464 IC50 > 50000.0 nM -
CHEMBL4075935 IC50 > 50000.0 nM -
CHEMBL4086050 IC50 > 50000.0 nM -
CHEMBL4073113 IC50 > 50000.0 nM -
CHEMBL4083530 IC50 > 50000.0 nM -