Assay Detail
Functional
CHEMBL3996773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-plasmodial activity against multidrug resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097733 | — | — | 1 | 7.70 |
| CHEMBL4093636 | — | — | 1 | 7.52 |
| CHEMBL4095280 | — | — | 1 | 7.52 |
| CHEMBL4068923 | — | — | 1 | 7.40 |
| CHEMBL1800559 | — | — | 1 | 6.96 |
| CHEMBL4062856 | — | — | 1 | 6.92 |
| CHEMBL4084045 | — | — | 1 | 6.89 |
| CHEMBL4081540 | — | — | 1 | 6.77 |
| CHEMBL4090006 | — | — | 1 | 6.72 |
| CHEMBL4092272 | — | — | 1 | 6.70 |
| CHEMBL4082152 | — | — | 1 | 6.68 |
| CHEMBL4079700 | — | — | 1 | 6.62 |
| CHEMBL4105454 | — | — | 1 | 6.58 |
| CHEMBL4061812 | — | — | 1 | 6.48 |
| CHEMBL4100993 | — | — | 1 | 6.47 |
| CHEMBL4071316 | — | — | 1 | 6.40 |
| CHEMBL4074246 | — | — | 1 | 6.37 |
| CHEMBL4071489 | — | — | 1 | 6.36 |
| CHEMBL4092279 | — | — | 1 | 6.34 |
| CHEMBL4099549 | — | — | 1 | 6.33 |
| CHEMBL4097620 | — | — | 1 | 6.27 |
| CHEMBL4070434 | — | — | 1 | 6.17 |
| CHEMBL4084546 | — | — | 1 | 6.16 |
| CHEMBL4085896 | — | — | 1 | 6.10 |
| CHEMBL4079203 | — | — | 1 | 6.09 |
| CHEMBL4097609 | — | — | 1 | 6.09 |
| CHEMBL4062329 | — | — | 1 | 6.08 |
| CHEMBL4088794 | — | — | 1 | 6.05 |
| CHEMBL4089718 | — | — | 1 | 6.02 |
| CHEMBL4070446 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097733 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4093636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4095280 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4068923 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1800559 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4062856 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4084045 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4081540 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4090006 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4092272 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4082152 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4079700 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4105454 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4061812 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4100993 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4071316 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4074246 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4071489 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4092279 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4099549 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4097620 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4070434 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4084546 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4085896 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4079203 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4097609 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4062329 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4088794 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4089718 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4070446 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4084534 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4070265 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4065621 | — | IC50 | = | 1070.0 | nM | 5.97 |