Assay Detail
Functional
CHEMBL3996812
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Anti-plasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 late 4/5 stage gametocytes assessed as reduction in ATP levels after 24 hrs by BacTiter-Glo reagent based bioluminescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.98 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.85 |
| CHEMBL4070434 | — | — | 1 | 6.34 |
| CHEMBL4100993 | — | — | 1 | 6.31 |
| CHEMBL4062856 | — | — | 1 | 6.23 |
| CHEMBL4097609 | — | — | 1 | 6.17 |
| CHEMBL4074246 | — | — | 1 | 6.16 |
| CHEMBL4097733 | — | — | 1 | 6.14 |
| CHEMBL4085896 | — | — | 1 | 5.99 |
| CHEMBL4079203 | — | — | 1 | 5.94 |
| CHEMBL4065621 | — | — | 1 | 5.84 |
| CHEMBL4071478 | — | — | 1 | 5.78 |
| CHEMBL4097620 | — | — | 1 | 5.75 |
| CHEMBL4073686 | — | — | 1 | 5.59 |
| CHEMBL4092272 | — | — | 1 | 5.58 |
| CHEMBL4071316 | — | — | 1 | 5.52 |
| CHEMBL4084534 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4070434 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4100993 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4062856 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4097609 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4074246 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4097733 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4085896 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4079203 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4065621 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4071478 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4097620 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4073686 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4092272 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4071316 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4084534 | — | IC50 | = | 3630.0 | nM | 5.44 |