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Assay Detail

CHEMBL3996942

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania braziliensis MHOM/CO/87/UA301 promastigote forms isolated from infected Balb/c mouse by neubauer chamber method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania braziliensis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania braziliensis (CHEMBL612878)
Type ORGANISM
Organism Leishmania braziliensis

Publication

Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against Leishmania braziliensis.
Romero AH, Medina R, Alcala A, García-Marchan Y, Núñez-Duran J, Leañez J, Mijoba A, Ciangherotti C, Serrano-Martín X, López SE.
Eur J Med Chem (2017) 127 : 606 -620
PubMed 28119201 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 6.21 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4062252 1 6.92
CHEMBL4083971 1 5.50
CHEMBL4086640 1 -
CHEMBL4065199 1 -
CHEMBL4097032 1 -
CHEMBL1353587 1 -
CHEMBL4089332 1 -
CHEMBL4061170 1 -
CHEMBL3212735 1 -
CHEMBL4099478 1 -
CHEMBL4070871 1 -
CHEMBL1992801 1 -
CHEMBL4072050 1 -
CHEMBL4099014 1 -
CHEMBL4082525 1 -
CHEMBL4060652 1 -
CHEMBL4090362 1 -
CHEMBL4069328 1 -
CHEMBL4098089 1 -
CHEMBL125 MILTEFOSINE 4.0 1 -
CHEMBL4091740 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4062252 EC50 = 120.0 nM 6.92
CHEMBL4083971 EC50 = 3200.0 nM 5.50
CHEMBL4086640 EC50 > 20000.0 nM -
CHEMBL4065199 EC50 < 20000.0 nM -
CHEMBL4097032 EC50 > 20000.0 nM -
CHEMBL1353587 EC50 > 20000.0 nM -
CHEMBL4089332 EC50 > 20000.0 nM -
CHEMBL4061170 EC50 > 20000.0 nM -
CHEMBL3212735 EC50 > 20000.0 nM -
CHEMBL4099478 EC50 > 20000.0 nM -
CHEMBL4070871 EC50 > 20000.0 nM -
CHEMBL1992801 EC50 > 20000.0 nM -
CHEMBL4072050 EC50 > 20000.0 nM -
CHEMBL4099014 EC50 > 20000.0 nM -
CHEMBL4082525 EC50 > 20000.0 nM -
CHEMBL4060652 EC50 > 20000.0 nM -
CHEMBL4090362 EC50 > 20000.0 nM -
CHEMBL4069328 EC50 > 20000.0 nM -
CHEMBL4098089 EC50 > 20000.0 nM -
CHEMBL125 MILTEFOSINE EC50 <= 20000.0 nM -
CHEMBL4091740 EC50 >= 20000.0 nM -