Assay Detail
Binding
CHEMBL3998013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.42 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 6.65 |
| CHEMBL4084567 | — | — | 1 | 6.57 |
| CHEMBL4095208 | — | — | 1 | 6.54 |
| CHEMBL458767 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | EC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4084567 | — | EC50 | = | 271.0 | nM | 6.57 |
| CHEMBL4095208 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL458767 | — | EC50 | = | 1250.0 | nM | 5.90 |