Assay Detail
Binding
CHEMBL3998326
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Inhibition of FGFR2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.98 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065323 | — | — | 1 | 8.40 |
| CHEMBL189584 | PD-173074 | — | 1 | 8.30 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | 2.0 | 1 | 8.12 |
| CHEMBL2220486 | LUCITANIB | 2.0 | 1 | 7.08 |
| CHEMBL4092990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065323 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL189584 | PD-173074 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2220486 | LUCITANIB | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL4092990 | — | IC50 | < | 1.0 | nM | - |