Assay Detail
Binding
CHEMBL3998352
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Inhibition of FGFR3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.36 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | 2.0 | 1 | 7.66 |
| CHEMBL4092990 | — | — | 1 | 7.39 |
| CHEMBL4065323 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4092990 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4065323 | — | IC50 | = | 93.0 | nM | 7.03 |