Assay Detail
Binding
CHEMBL3998489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 mV holding potential by whole cell patch-clamp method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.91 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079657 | — | — | 1 | 7.31 |
| CHEMBL227934 | STRYCHNINE | -1.0 | 1 | 7.29 |
| CHEMBL4103909 | — | — | 1 | 7.23 |
| CHEMBL4060962 | — | — | 1 | 7.12 |
| CHEMBL4102677 | — | — | 1 | 7.12 |
| CHEMBL4089150 | — | — | 1 | 7.09 |
| CHEMBL4068867 | — | — | 1 | 6.96 |
| CHEMBL4096857 | — | — | 1 | 6.70 |
| CHEMBL4069635 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079657 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL227934 | STRYCHNINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4103909 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4060962 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4102677 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4089150 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4068867 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4096857 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL4069635 | — | IC50 | = | 4590.0 | nM | 5.34 |