Assay Detail
Functional
CHEMBL3998531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H460 cells assessed as decrease in cell proliferation after 72 hrs by Alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.20 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103308 | — | — | 1 | 5.46 |
| CHEMBL4079048 | — | — | 1 | 5.46 |
| CHEMBL4065472 | — | — | 1 | 5.32 |
| CHEMBL4086902 | — | — | 1 | 5.31 |
| CHEMBL4094619 | — | — | 1 | 5.17 |
| CHEMBL4074087 | — | — | 1 | 5.03 |
| CHEMBL4060557 | — | — | 1 | 4.93 |
| CHEMBL4082441 | — | — | 1 | 4.93 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103308 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL4079048 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL4065472 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4086902 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL4094619 | — | IC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL4074087 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL4060557 | — | IC50 | = | 11680.0 | nM | 4.93 |
| CHEMBL4082441 | — | IC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - |