Assay Detail
Functional
CHEMBL3998645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 58 | 6.78 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.10 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.10 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.64 |
| CHEMBL4069899 | — | — | 1 | 7.58 |
| CHEMBL4096235 | — | — | 1 | 7.57 |
| CHEMBL4070931 | — | — | 1 | 7.55 |
| CHEMBL4075337 | — | — | 1 | 7.46 |
| CHEMBL4074904 | — | — | 1 | 7.39 |
| CHEMBL4101637 | — | — | 1 | 7.38 |
| CHEMBL4089393 | — | — | 1 | 7.29 |
| CHEMBL4092899 | — | — | 1 | 7.25 |
| CHEMBL4095346 | — | — | 1 | 7.24 |
| CHEMBL4079771 | — | — | 1 | 7.24 |
| CHEMBL4061235 | — | — | 1 | 7.19 |
| CHEMBL585136 | — | — | 1 | 7.11 |
| CHEMBL4078263 | — | — | 1 | 7.11 |
| CHEMBL4085157 | — | — | 1 | 6.99 |
| CHEMBL4089468 | — | — | 1 | 6.98 |
| CHEMBL4083637 | — | — | 1 | 6.98 |
| CHEMBL4099149 | — | — | 1 | 6.96 |
| CHEMBL579127 | — | — | 1 | 6.96 |
| CHEMBL1198629 | — | — | 1 | 6.95 |
| CHEMBL1197739 | — | — | 1 | 6.95 |
| CHEMBL4066555 | — | — | 1 | 6.94 |
| CHEMBL4102531 | — | — | 1 | 6.93 |
| CHEMBL4103101 | — | — | 1 | 6.92 |
| CHEMBL533658 | — | — | 1 | 6.91 |
| CHEMBL379386 | — | — | 1 | 6.90 |
| CHEMBL4072187 | — | — | 1 | 6.89 |
| CHEMBL4073228 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4069899 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4096235 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4070931 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4075337 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4074904 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4101637 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4089393 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4092899 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4095346 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4079771 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4061235 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4078263 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL585136 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4085157 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4089468 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4083637 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4099149 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL579127 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1198629 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1197739 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4066555 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4102531 | — | EC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4103101 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL533658 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL379386 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4072187 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4073228 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1198227 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4075170 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4065240 | — | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL580160 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3809699 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL592582 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4100552 | — | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL1198335 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL598279 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4082535 | — | EC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4093909 | — | EC50 | = | 283.0 | nM | 6.55 |
| CHEMBL581649 | — | EC50 | = | 317.0 | nM | 6.50 |
| CHEMBL4079996 | — | EC50 | = | 329.0 | nM | 6.48 |
| CHEMBL4095579 | — | EC50 | = | 418.0 | nM | 6.38 |
| CHEMBL1197812 | — | EC50 | = | 526.0 | nM | 6.28 |
| CHEMBL4087651 | — | EC50 | = | 539.0 | nM | 6.27 |
| CHEMBL4095232 | — | EC50 | = | 569.0 | nM | 6.25 |
| CHEMBL1198345 | — | EC50 | = | 574.0 | nM | 6.24 |
| CHEMBL4066296 | — | EC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4067815 | — | EC50 | = | 691.0 | nM | 6.16 |