Assay Detail
Functional
CHEMBL3998652
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Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.28 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.22 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.22 |
| CHEMBL4069899 | — | — | 1 | 7.31 |
| CHEMBL4075337 | — | — | 1 | 7.27 |
| CHEMBL4096235 | — | — | 1 | 7.24 |
| CHEMBL4070931 | — | — | 1 | 7.21 |
| CHEMBL4103101 | — | — | 1 | 7.12 |
| CHEMBL4092899 | — | — | 1 | 7.10 |
| CHEMBL4101637 | — | — | 1 | 6.91 |
| CHEMBL4065240 | — | — | 1 | 6.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4069899 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4075337 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4096235 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4070931 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4103101 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4092899 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4101637 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4065240 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 250.0 | nM | 6.60 |