Assay Detail
Functional
CHEMBL3998656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.54 |
| CHEMBL4069899 | — | — | 1 | 6.49 |
| CHEMBL4096235 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4069899 | — | EC50 | = | 323.0 | nM | 6.49 |
| CHEMBL4096235 | — | EC50 | = | 637.0 | nM | 6.20 |