Assay Detail
Binding
CHEMBL3999640
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Displacement of [3H]N-methylspiperone from human dopamine D3 receptor after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.45 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1457510 | — | — | 1 | 7.08 |
| CHEMBL2334885 | — | — | 1 | 6.58 |
| CHEMBL490533 | CANADINE | — | 1 | 6.36 |
| CHEMBL448891 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1457510 | — | Ki | = | 82.4 | nM | 7.08 |
| CHEMBL2334885 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL490533 | CANADINE | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL448891 | — | Ki | = | 1713.0 | nM | 5.77 |