Assay Detail
Binding
CHEMBL3999647
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Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.27 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2334891 | — | — | 1 | 8.02 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2334891 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL487182 | TETRAHYDROPALMATINE | Ki | = | 305.0 | nM | 6.52 |