Assay Detail
Binding
CHEMBL3999828
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Inhibition of Proteus mirabilis 543 urease at pH 5.5 assessed as reduction in ammonia production using urea as substrate preincubated for 120 mins followed by substrate addition measured after 15 mins by NaOH-hypochlorite method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Proteus mirabilis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.09 | 4.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503160 | FUMARIC ACID | 3.0 | 1 | 4.18 |
| CHEMBL1874364 | — | — | 1 | 4.05 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.04 |
| CHEMBL318196 | ETHYL CINNAMATE | — | 1 | - |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503160 | FUMARIC ACID | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL1874364 | — | IC50 | = | 88600.0 | nM | 4.05 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 91400.0 | nM | 4.04 |
| CHEMBL318196 | ETHYL CINNAMATE | IC50 | - | — | - | |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 125000.0 | nM | - |