Assay Detail
Functional
CHEMBL3999840
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Antiproliferative activity against human A549 cells harboring wild type EGFR after 48 hrs by MTT assay
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.13 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094174 | — | — | 1 | 6.06 |
| CHEMBL4067373 | — | — | 1 | 6.04 |
| CHEMBL4100647 | — | — | 1 | 5.44 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.30 |
| CHEMBL4063301 | — | — | 1 | 5.20 |
| CHEMBL4094823 | — | — | 1 | 5.07 |
| CHEMBL4082840 | — | — | 2 | 4.75 |
| CHEMBL4088200 | — | — | 2 | 4.74 |
| CHEMBL4091166 | — | — | 1 | 4.58 |
| CHEMBL1830034 | — | — | 1 | - |
| CHEMBL343352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094174 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4067373 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4100647 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4063301 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL4094823 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL4082840 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4088200 | — | IC50 | = | 18270.0 | nM | 4.74 |
| CHEMBL4082840 | — | IC50 | = | 24740.0 | nM | 4.61 |
| CHEMBL4088200 | — | IC50 | = | 25290.0 | nM | 4.60 |
| CHEMBL4091166 | — | IC50 | = | 26120.0 | nM | 4.58 |
| CHEMBL1830034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL343352 | — | IC50 | > | 100000.0 | nM | - |