Assay Detail
Functional
CHEMBL3999952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine resistant Plasmodium falciparum K1 erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and activity of nucleoside-based antiprotozoan compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.99 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.85 |
| CHEMBL4075657 | — | — | 1 | 6.05 |
| CHEMBL4060076 | — | — | 1 | 5.96 |
| CHEMBL4070000 | — | — | 1 | 5.82 |
| CHEMBL4091995 | — | — | 1 | 5.55 |
| CHEMBL4074699 | — | — | 1 | 5.41 |
| CHEMBL4093177 | — | — | 1 | 5.24 |
| CHEMBL4090399 | — | — | 1 | 5.10 |
| CHEMBL4084731 | — | — | 1 | 5.01 |
| CHEMBL4097315 | — | — | 1 | 5.00 |
| CHEMBL4076916 | — | — | 1 | 4.92 |
| CHEMBL4076818 | — | — | 1 | 4.89 |
| CHEMBL4076721 | — | — | 1 | 4.85 |
| CHEMBL4094270 | — | — | 1 | 4.72 |
| CHEMBL4066090 | — | — | 1 | 4.72 |
| CHEMBL4071448 | — | — | 1 | 4.69 |
| CHEMBL4100225 | — | — | 1 | 4.64 |
| CHEMBL4085214 | — | — | 1 | 4.60 |
| CHEMBL4081985 | — | — | 1 | 4.54 |
| CHEMBL4105508 | — | — | 1 | 4.43 |
| CHEMBL4091532 | — | — | 1 | 4.35 |
| CHEMBL4067099 | — | — | 1 | 4.19 |
| CHEMBL4062813 | — | — | 1 | 4.17 |
| CHEMBL4073644 | — | — | 1 | 4.06 |
| CHEMBL4085977 | — | — | 1 | - |
| CHEMBL4088363 | — | — | 1 | - |
| CHEMBL4093664 | — | — | 1 | - |
| CHEMBL4090762 | — | — | 1 | - |
| CHEMBL4061466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4075657 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4060076 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4070000 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4091995 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4074699 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4093177 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4090399 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4084731 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4097315 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4076916 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4076818 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4076721 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4094270 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4066090 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4071448 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4100225 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4085214 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4081985 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4105508 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4091532 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4067099 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4062813 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4073644 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL4085977 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL4088363 | — | IC50 | > | 170000.0 | nM | - |
| CHEMBL4093664 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL4090762 | — | IC50 | > | 168000.0 | nM | - |
| CHEMBL4061466 | — | IC50 | = | 106000.0 | nM | - |