Assay Detail
Binding
CHEMBL3999984
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Inhibition of human N-terminal His-tagged IDO1 expressed in Escherichia coli using D-Trp as substrate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.88 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565923 | — | — | 1 | 7.30 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL584991 | — | — | 1 | 7.12 |
| CHEMBL3955791 | — | — | 1 | 7.00 |
| CHEMBL4076756 | — | — | 1 | 7.00 |
| CHEMBL3979473 | — | — | 1 | 6.92 |
| CHEMBL4072733 | — | — | 1 | 6.77 |
| CHEMBL4085426 | — | — | 1 | 6.75 |
| CHEMBL4091895 | — | — | 1 | 6.70 |
| CHEMBL4083203 | — | — | 1 | 6.68 |
| CHEMBL4064144 | — | — | 1 | 6.64 |
| CHEMBL4099627 | — | — | 1 | 6.54 |
| CHEMBL4063847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565923 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL584991 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3955791 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4076756 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3979473 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4072733 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4085426 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4091895 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4083203 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4064144 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4099627 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4063847 | — | IC50 | > | 5000.0 | nM | - |