Assay Detail
Binding
CHEMBL3999985
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Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.58 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.13 |
| CHEMBL565923 | — | — | 1 | 8.00 |
| CHEMBL3979473 | — | — | 1 | 7.96 |
| CHEMBL4076756 | — | — | 1 | 7.85 |
| CHEMBL3955791 | — | — | 1 | 7.80 |
| CHEMBL4083203 | — | — | 1 | 7.77 |
| CHEMBL584991 | — | — | 1 | 7.72 |
| CHEMBL4072733 | — | — | 1 | 7.66 |
| CHEMBL4085426 | — | — | 1 | 7.46 |
| CHEMBL4099627 | — | — | 1 | 7.01 |
| CHEMBL4091895 | — | — | 1 | 7.00 |
| CHEMBL4064144 | — | — | 1 | 6.55 |
| CHEMBL4063847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL565923 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3979473 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4076756 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3955791 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4083203 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL584991 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4072733 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4085426 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4099627 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4091895 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4064144 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4063847 | — | IC50 | > | 5000.0 | nM | - |