Assay Detail
Functional
CHEMBL4000266
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Agonist activity at CB1 receptor in rat brain membranes assessed as reduction in forskolin-stimulated cAMP level measured from 8 data points after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.25 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104362 | — | — | 1 | 9.40 |
| CHEMBL3104360 | — | — | 1 | 9.30 |
| CHEMBL4071389 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104362 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3104360 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4071389 | — | EC50 | = | 0.9 | nM | 9.05 |