Assay Detail
Binding
CHEMBL4000279
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Displacement of [3H]NMS from human mAChR1 receptor expressed in F1pIn CHO cells after 60 mins by scintillation counting analysis
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.39 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093980 | — | — | 2 | 5.73 |
| CHEMBL4062602 | — | — | 2 | 5.49 |
| CHEMBL4090568 | — | — | 2 | 5.38 |
| CHEMBL4104013 | — | — | 2 | 5.37 |
| CHEMBL4066435 | — | — | 2 | 5.29 |
| CHEMBL1242923 | — | — | 2 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093980 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL4093980 | — | IC50 | = | 1872.0 | nM | 5.73 |
| CHEMBL4062602 | — | IC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL4062602 | — | IC50 | = | 3253.0 | nM | 5.49 |
| CHEMBL4090568 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL4090568 | — | IC50 | = | 4191.0 | nM | 5.38 |
| CHEMBL4104013 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL4104013 | — | IC50 | = | 4259.0 | nM | 5.37 |
| CHEMBL4066435 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL4066435 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL1242923 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL1242923 | — | IC50 | = | 8525.0 | nM | 5.07 |