Assay Detail
Binding
CHEMBL4000282
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Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in F1pIn CHO cell membranes after 1 hr by scintillation counting method
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.12 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062602 | — | — | 2 | 8.57 |
| CHEMBL4090568 | — | — | 2 | 8.24 |
| CHEMBL4093980 | — | — | 2 | 7.12 |
| CHEMBL4066435 | — | — | 2 | 6.56 |
| CHEMBL4104013 | — | — | 2 | 6.25 |
| CHEMBL1242923 | — | — | 2 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062602 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL4062602 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4090568 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL4090568 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4093980 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL4093980 | — | Ki | = | 75.8 | nM | 7.12 |
| CHEMBL4066435 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL4066435 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL4104013 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL4104013 | — | Ki | = | 568.0 | nM | 6.25 |
| CHEMBL1242923 | — | Ki | = | 1047.13 | nM | 5.98 |
| CHEMBL1242923 | — | Ki | = | 1042.0 | nM | 5.98 |