Assay Detail
Functional
CHEMBL4000286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mAChR1 receptor expressed in F1pIn CHO cells assessed as induction of intracellular calcium mobilization
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 4 | - | - |
| EC50 | 2 | 6.89 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242923 | — | — | 2 | 6.89 |
| CHEMBL4093980 | — | — | 1 | - |
| CHEMBL4066435 | — | — | 1 | - |
| CHEMBL4062602 | — | — | 1 | - |
| CHEMBL4104013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242923 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL1242923 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4093980 | — | pEC50 | - | — | - | |
| CHEMBL4066435 | — | pEC50 | - | — | - | |
| CHEMBL4062602 | — | pEC50 | - | — | - | |
| CHEMBL4104013 | — | pEC50 | - | — | - |