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Assay Detail

CHEMBL4000403

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds.
Eaton AL, Dalal S, Cassera MB, Zhao S, Kingston DG.
J Nat Prod (2016) 79 : 1679 -1683
PubMed 27228055 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.68 6.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4074882 1 6.25
CHEMBL4101567 1 6.24
CHEMBL4078197 1 5.77
CHEMBL4066265 1 5.77
CHEMBL4068931 1 5.70
CHEMBL4090011 1 5.44
CHEMBL1242095 1 5.18
CHEMBL4064452 1 5.09
CHEMBL4096247 1 -
CHEMBL4086089 1 -
CHEMBL4104009 1 -
CHEMBL490514 1 -
CHEMBL4089474 1 -
CHEMBL452477 2,4,6-TRIHYDROXYACETOPHENONE 1 -
CHEMBL1241050 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4074882 IC50 = 560.0 nM 6.25
CHEMBL4101567 IC50 = 570.0 nM 6.24
CHEMBL4078197 IC50 = 1700.0 nM 5.77
CHEMBL4066265 IC50 = 1700.0 nM 5.77
CHEMBL4068931 IC50 = 2000.0 nM 5.70
CHEMBL4090011 IC50 = 3600.0 nM 5.44
CHEMBL1242095 IC50 = 6600.0 nM 5.18
CHEMBL4064452 IC50 = 8100.0 nM 5.09
CHEMBL4096247 IC50 > 10000.0 nM -
CHEMBL4086089 IC50 > 20000.0 nM -
CHEMBL4104009 IC50 > 10000.0 nM -
CHEMBL490514 IC50 > 20000.0 nM -
CHEMBL4089474 IC50 > 20000.0 nM -
CHEMBL452477 2,4,6-TRIHYDROXYACETOPHENONE IC50 > 20000.0 nM -
CHEMBL1241050 IC50 > 20000.0 nM -