Assay Detail
Binding
CHEMBL4000508
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Inhibition of telomerase activity in human MDA-MB-435 cell lysate measured after 24 hrs by TRAP assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting telomerase with radiolabeled inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 2 | 6.22 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170856 | — | — | 2 | 6.64 |
| CHEMBL4097807 | — | — | 2 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170856 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4097807 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2170856 | — | Inhibition | - | % | - | |
| CHEMBL4097807 | — | Inhibition | - | % | - |