Assay Detail
Binding
CHEMBL4000778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as substrate after 60 mins by UV-HPLC method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.59 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097068 | — | — | 1 | 8.00 |
| CHEMBL1800991 | — | — | 1 | 8.00 |
| CHEMBL30108 | — | — | 1 | 7.96 |
| CHEMBL1085637 | — | — | 1 | 7.92 |
| CHEMBL4079052 | — | — | 1 | 7.82 |
| CHEMBL1801026 | — | — | 1 | 7.66 |
| CHEMBL4086908 | — | — | 1 | 7.64 |
| CHEMBL4067166 | — | — | 1 | 7.51 |
| CHEMBL205892 | — | — | 1 | 7.46 |
| CHEMBL4100466 | — | — | 1 | 7.31 |
| CHEMBL1800992 | — | — | 1 | 7.15 |
| CHEMBL1801024 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097068 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1800991 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL30108 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1085637 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4079052 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1801026 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4086908 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4067166 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL205892 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4100466 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1800992 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1801024 | — | IC50 | = | 210.0 | nM | 6.68 |