Assay Detail
Binding
CHEMBL4001302
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Inhibition of bisamide probe binding to pirin in human SKOV3 cells by SILAC-based quantitative mass spectrometry pull down assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| AC50 | 2 | 5.41 | 5.82 |
| Ki | 2 | 7.14 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087666 | — | — | 2 | 7.55 |
| CHEMBL4096048 | — | — | 2 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087666 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL4096048 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4087666 | — | AC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4096048 | — | AC50 | = | 10000.0 | nM | 5.00 |