Assay Detail
Functional
CHEMBL4001433
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Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkynyloxy derivatives of 5,8-quinolinedione: Synthesis, in vitro cytotoxicity studies and computational molecular modeling with NAD(P)H:Quinone oxidoreductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.96 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075729 | — | — | 1 | 5.74 |
| CHEMBL4074815 | — | — | 1 | 5.63 |
| CHEMBL4092957 | — | — | 1 | 5.21 |
| CHEMBL4085063 | — | — | 1 | 4.99 |
| CHEMBL4072196 | — | — | 1 | 4.93 |
| CHEMBL4093780 | — | — | 1 | 4.86 |
| CHEMBL4090511 | — | — | 1 | 4.86 |
| CHEMBL4066202 | — | — | 1 | 4.77 |
| CHEMBL4063258 | — | — | 1 | 4.67 |
| CHEMBL4075760 | — | — | 1 | 4.63 |
| CHEMBL132160 | — | — | 1 | 4.60 |
| CHEMBL4080328 | — | — | 1 | 4.59 |
| CHEMBL4075555 | — | — | 1 | - |
| CHEMBL4082690 | — | — | 1 | - |
| CHEMBL4100681 | — | — | 1 | - |
| CHEMBL4076551 | — | — | 1 | - |
| CHEMBL4103941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075729 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4074815 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4092957 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL4085063 | — | IC50 | = | 10240.0 | nM | 4.99 |
| CHEMBL4072196 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL4093780 | — | IC50 | = | 13720.0 | nM | 4.86 |
| CHEMBL4090511 | — | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL4066202 | — | IC50 | = | 17010.0 | nM | 4.77 |
| CHEMBL4063258 | — | IC50 | = | 21380.0 | nM | 4.67 |
| CHEMBL4075760 | — | IC50 | = | 23190.0 | nM | 4.63 |
| CHEMBL132160 | — | IC50 | = | 24960.0 | nM | 4.60 |
| CHEMBL4080328 | — | IC50 | = | 25560.0 | nM | 4.59 |
| CHEMBL4075555 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4082690 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4100681 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4076551 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4103941 | — | IC50 | > | 30000.0 | nM | - |