Assay Detail
Functional
CHEMBL4001497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 4.57 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 7.74 |
| CHEMBL4097148 | — | — | 1 | 5.59 |
| CHEMBL4073781 | — | — | 1 | 5.47 |
| CHEMBL4081572 | — | — | 1 | 5.30 |
| CHEMBL4100531 | — | — | 1 | 5.14 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.82 |
| CHEMBL4095480 | — | — | 1 | 4.71 |
| CHEMBL4084843 | — | — | 1 | 4.71 |
| CHEMBL4071529 | — | — | 1 | 4.67 |
| CHEMBL3134060 | — | — | 1 | 4.65 |
| CHEMBL4070993 | — | — | 1 | 4.57 |
| CHEMBL12798 | METHYL DEHYDROABIETATE | — | 1 | 4.42 |
| CHEMBL4095206 | — | — | 1 | 4.32 |
| CHEMBL4105419 | — | — | 1 | 4.31 |
| CHEMBL4096942 | — | — | 1 | 4.30 |
| CHEMBL4068950 | — | — | 1 | 4.30 |
| CHEMBL12850 | DEHYDROABIETIC ACID | — | 1 | 4.29 |
| CHEMBL4090755 | — | — | 1 | 4.25 |
| CHEMBL4068827 | — | — | 1 | 4.24 |
| CHEMBL4075631 | — | — | 1 | 4.22 |
| CHEMBL4100065 | — | — | 1 | 4.19 |
| CHEMBL4100486 | — | — | 1 | 4.17 |
| CHEMBL509586 | METHYL ABIETATE | — | 1 | 4.10 |
| CHEMBL4092315 | — | — | 1 | 4.09 |
| CHEMBL4103882 | — | — | 1 | 4.04 |
| CHEMBL4086478 | — | — | 1 | 4.02 |
| CHEMBL4073668 | — | — | 1 | 4.01 |
| CHEMBL4061282 | — | — | 1 | 4.01 |
| CHEMBL4089923 | — | — | 1 | 4.00 |
| CHEMBL4096124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL4097148 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL4073781 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4081572 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL4100531 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 15310.0 | nM | 4.82 |
| CHEMBL4095480 | — | IC50 | = | 19370.0 | nM | 4.71 |
| CHEMBL4084843 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL4071529 | — | IC50 | = | 21130.0 | nM | 4.67 |
| CHEMBL3134060 | — | IC50 | = | 22330.0 | nM | 4.65 |
| CHEMBL4070993 | — | IC50 | = | 27210.0 | nM | 4.57 |
| CHEMBL12798 | METHYL DEHYDROABIETATE | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL4095206 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4105419 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL4068950 | — | IC50 | = | 50130.0 | nM | 4.30 |
| CHEMBL4096942 | — | IC50 | = | 50430.0 | nM | 4.30 |
| CHEMBL12850 | DEHYDROABIETIC ACID | IC50 | = | 51310.0 | nM | 4.29 |
| CHEMBL4090755 | — | IC50 | = | 55930.0 | nM | 4.25 |
| CHEMBL4068827 | — | IC50 | = | 58020.0 | nM | 4.24 |
| CHEMBL4075631 | — | IC50 | = | 59850.0 | nM | 4.22 |
| CHEMBL4100065 | — | IC50 | = | 64160.0 | nM | 4.19 |
| CHEMBL4100486 | — | IC50 | = | 68040.0 | nM | 4.17 |
| CHEMBL509586 | METHYL ABIETATE | IC50 | = | 79320.0 | nM | 4.10 |
| CHEMBL4092315 | — | IC50 | = | 81930.0 | nM | 4.09 |
| CHEMBL4103882 | — | IC50 | = | 92210.0 | nM | 4.04 |
| CHEMBL4086478 | — | IC50 | = | 95120.0 | nM | 4.02 |
| CHEMBL4061282 | — | IC50 | = | 98250.0 | nM | 4.01 |
| CHEMBL4073668 | — | IC50 | = | 98340.0 | nM | 4.01 |
| CHEMBL4089923 | — | IC50 | = | 99410.0 | nM | 4.00 |
| CHEMBL4075541 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71893 | ABIETIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091836 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091119 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4081847 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4099576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4069947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4070997 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4077593 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4079624 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4077044 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4074737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4087501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3039217 | TRIPTOPHENOLIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4096124 | — | IC50 | > | 100000.0 | nM | - |