Assay Detail
Binding
CHEMBL4001872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma brucei His6-tagged HK1 expressed in Escherichia coli M15(pREP) harboring pQE30 using glucose as substrate after 2 hrs by spectrophotometric based glucose 6-phosphate dehydrogenase enzyme coupled assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Evaluation of substituted ebselen derivatives as potential trypanocidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.50 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 7.30 |
| CHEMBL45152 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL45152 | — | IC50 | = | 2000.0 | nM | 5.70 |