Assay Detail
Binding
CHEMBL4001969
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Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of furan carboxylate derivatives as novel inhibitors of ATP-citrate lyase via virtual high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.40 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399379 | — | — | 1 | 6.42 |
| CHEMBL4094117 | — | — | 1 | 5.39 |
| CHEMBL4072433 | — | — | 1 | 4.92 |
| CHEMBL4061755 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399379 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL4094117 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4072433 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4061755 | — | IC50 | = | 13800.0 | nM | 4.86 |