Assay Detail
Functional
CHEMBL4002263
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.00 |
| CHEMBL4096150 | — | — | 1 | 6.96 |
| CHEMBL4078097 | — | — | 1 | 6.96 |
| CHEMBL4067087 | — | — | 1 | 6.70 |
| CHEMBL4089296 | — | — | 1 | 6.70 |
| CHEMBL4063416 | — | — | 1 | 6.40 |
| CHEMBL4094557 | — | — | 1 | 5.82 |
| CHEMBL1775213 | — | — | 1 | 5.77 |
| CHEMBL4096159 | — | — | 1 | 5.60 |
| CHEMBL4080573 | — | — | 1 | 4.89 |
| CHEMBL4076062 | — | — | 1 | 4.89 |
| CHEMBL4069887 | — | — | 1 | 4.47 |
| CHEMBL4091783 | — | — | 1 | 4.46 |
| CHEMBL4104721 | — | — | 1 | 4.42 |
| CHEMBL4095657 | — | — | 1 | 4.39 |
| CHEMBL1775215 | — | — | 1 | - |
| CHEMBL4079669 | — | — | 1 | - |
| CHEMBL1079637 | — | — | 1 | - |
| CHEMBL4104800 | — | — | 1 | - |
| CHEMBL4097086 | — | — | 1 | - |
| CHEMBL4078105 | — | — | 1 | - |
| CHEMBL4088436 | — | — | 1 | - |
| CHEMBL4067178 | — | — | 1 | - |
| CHEMBL4070915 | — | — | 1 | - |
| CHEMBL4067172 | — | — | 1 | - |
| CHEMBL4088428 | — | — | 1 | - |
| CHEMBL4078981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4096150 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4078097 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4067087 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4089296 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4063416 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4094557 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1775213 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4096159 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4080573 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4076062 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4069887 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4091783 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4104721 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL4095657 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1775215 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4079669 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1079637 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4104800 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL4097086 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4078105 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4088436 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4067178 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4070915 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4067172 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4088428 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4078981 | — | IC50 | > | 80000.0 | nM | - |