Assay Detail
Binding
CHEMBL4002927
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Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 2 to 5 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2,3-Triazolyl ester of Ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.54 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067898 | — | — | 1 | 8.22 |
| CHEMBL469 | KETOROLAC | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067898 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL469 | KETOROLAC | IC50 | = | 140.0 | nM | 6.85 |