Assay Detail
Binding
CHEMBL4003321
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Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured every 1 min for 30 mins by Dixon plot method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.21 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071069 | — | — | 1 | 7.05 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 6.40 |
| CHEMBL4063629 | — | — | 1 | 6.23 |
| CHEMBL3325723 | — | — | 1 | 6.12 |
| CHEMBL4085251 | — | — | 1 | 5.58 |
| CHEMBL4100709 | — | — | 1 | 5.51 |
| CHEMBL4099629 | — | — | 1 | 5.35 |
| CHEMBL4075135 | — | — | 1 | 5.19 |
| CHEMBL4063777 | — | — | 1 | 5.16 |
| CHEMBL4090532 | — | — | 1 | 5.14 |
| CHEMBL4082718 | — | — | 1 | 5.09 |
| CHEMBL4091899 | — | — | 1 | 5.07 |
| CHEMBL4081749 | — | — | 1 | 5.05 |
| CHEMBL4062429 | — | — | 1 | 4.97 |
| CHEMBL4084140 | — | — | 1 | 4.96 |
| CHEMBL4089507 | — | — | 1 | 4.93 |
| CHEMBL4072365 | — | — | 1 | 4.87 |
| CHEMBL4094059 | — | — | 1 | 4.85 |
| CHEMBL4078221 | — | — | 1 | 4.78 |
| CHEMBL4093124 | — | — | 1 | 4.69 |
| CHEMBL4062563 | — | — | 1 | 4.68 |
| CHEMBL4096275 | — | — | 1 | 4.68 |
| CHEMBL80460 | PLATANIC ACID | — | 1 | 4.50 |
| CHEMBL4081627 | — | — | 1 | 4.28 |
| CHEMBL4101798 | — | — | 1 | - |
| CHEMBL4066524 | — | — | 1 | - |
| CHEMBL4104205 | — | — | 1 | - |
| CHEMBL4086293 | — | — | 1 | - |
| CHEMBL4061347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071069 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL4063629 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3325723 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL4085251 | — | Ki | = | 2630.0 | nM | 5.58 |
| CHEMBL4100709 | — | Ki | = | 3060.0 | nM | 5.51 |
| CHEMBL4099629 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL4075135 | — | Ki | = | 6510.0 | nM | 5.19 |
| CHEMBL4063777 | — | Ki | = | 6960.0 | nM | 5.16 |
| CHEMBL4090532 | — | Ki | = | 7180.0 | nM | 5.14 |
| CHEMBL4082718 | — | Ki | = | 8160.0 | nM | 5.09 |
| CHEMBL4091899 | — | Ki | = | 8510.0 | nM | 5.07 |
| CHEMBL4081749 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4062429 | — | Ki | = | 10660.0 | nM | 4.97 |
| CHEMBL4084140 | — | Ki | = | 11010.0 | nM | 4.96 |
| CHEMBL4089507 | — | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL4072365 | — | Ki | = | 13370.0 | nM | 4.87 |
| CHEMBL4094059 | — | Ki | = | 14140.0 | nM | 4.85 |
| CHEMBL4078221 | — | Ki | = | 16710.0 | nM | 4.78 |
| CHEMBL4093124 | — | Ki | = | 20330.0 | nM | 4.69 |
| CHEMBL4062563 | — | Ki | = | 20900.0 | nM | 4.68 |
| CHEMBL4096275 | — | Ki | = | 20860.0 | nM | 4.68 |
| CHEMBL80460 | PLATANIC ACID | Ki | = | 31640.0 | nM | 4.50 |
| CHEMBL4081627 | — | Ki | = | 53050.0 | nM | 4.28 |
| CHEMBL4101798 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL4066524 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4104205 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4086293 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4061347 | — | Ki | > | 4000.0 | nM | - |