Assay Detail
Binding
CHEMBL4003400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.06 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.08 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.71 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4190.0 | nM | 5.38 |