Assay Detail
Binding
CHEMBL4003454
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST tagged human recombinant JAK1 catalytic domain expressed in baculovirus using peptide substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins by microfluidic assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.25 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3928932 | — | — | 1 | 9.40 |
| CHEMBL4093813 | — | — | 1 | 9.30 |
| CHEMBL4103980 | — | — | 1 | 9.10 |
| CHEMBL4086057 | — | — | 1 | 9.05 |
| CHEMBL4069951 | — | — | 1 | 8.89 |
| CHEMBL4096219 | — | — | 1 | 8.77 |
| CHEMBL4097152 | — | — | 1 | 8.74 |
| CHEMBL4066236 | — | — | 1 | 8.68 |
| CHEMBL3644620 | — | — | 1 | 8.66 |
| CHEMBL4089515 | — | — | 1 | 8.64 |
| CHEMBL3914503 | — | — | 1 | 8.21 |
| CHEMBL4078165 | — | — | 1 | 8.12 |
| CHEMBL4104931 | — | — | 1 | 8.01 |
| CHEMBL4087076 | — | — | 1 | 7.57 |
| CHEMBL4068357 | — | — | 1 | 7.43 |
| CHEMBL4101534 | — | — | 1 | 7.22 |
| CHEMBL3929865 | — | — | 1 | 7.16 |
| CHEMBL4074855 | — | — | 1 | 5.56 |
| CHEMBL3644618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3928932 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4093813 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4103980 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4086057 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4069951 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4096219 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4097152 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4066236 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3644620 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4089515 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3914503 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4078165 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4104931 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4087076 | — | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL4068357 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL4101534 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3929865 | — | IC50 | = | 68.6 | nM | 7.16 |
| CHEMBL4074855 | — | IC50 | = | 2756.5 | nM | 5.56 |
| CHEMBL3644618 | — | IC50 | < | 0.1 | nM | - |