Assay Detail
Binding
CHEMBL4003519
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Inhibition of PARP3 (unknown origin)
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP3 (CHEMBL5083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.37 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098188 | — | — | 2 | 4.40 |
| CHEMBL4069447 | — | — | 2 | 4.35 |
| CHEMBL4080163 | — | — | 1 | - |
| CHEMBL1892587 | — | — | 1 | - |
| CHEMBL4063631 | — | — | 1 | - |
| CHEMBL1956162 | — | — | 1 | - |
| CHEMBL4059827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098188 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL4098188 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4069447 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4069447 | — | IC50 | = | 45708.82 | nM | 4.34 |
| CHEMBL4080163 | — | IC50 | - | — | - | |
| CHEMBL1892587 | — | IC50 | - | — | - | |
| CHEMBL4063631 | — | IC50 | - | — | - | |
| CHEMBL1956162 | — | IC50 | - | — | - | |
| CHEMBL4059827 | — | IC50 | - | — | - |