Assay Detail
Binding
CHEMBL4003653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated ephrin-A1-Fc from recombinant mouse EphA2 receptor preincubated for 1 hr followed by biotinylated ephrin-A1-Fc addition measured after 4 hrs by ELISA method
23
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.01 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078429 | — | — | 2 | 6.10 |
| CHEMBL3735125 | — | — | 2 | 6.04 |
| CHEMBL4079387 | — | — | 2 | 5.75 |
| CHEMBL4087778 | — | — | 1 | 5.51 |
| CHEMBL4089696 | — | — | 1 | 5.41 |
| CHEMBL4087107 | — | — | 1 | 5.00 |
| CHEMBL4090681 | — | — | 1 | 4.89 |
| CHEMBL4099159 | — | — | 1 | 4.85 |
| CHEMBL4071291 | — | — | 1 | 4.77 |
| CHEMBL4081123 | — | — | 1 | 4.75 |
| CHEMBL4098329 | — | — | 2 | 4.58 |
| CHEMBL4081825 | — | — | 1 | 4.55 |
| CHEMBL4059908 | — | — | 2 | 4.55 |
| CHEMBL4064652 | — | — | 2 | 4.54 |
| CHEMBL408701 | TAUROLITHOCHOLIC ACID | 3.0 | 1 | 4.14 |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | 4.10 |
| CHEMBL4074295 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078429 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4078429 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3735125 | — | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL3735125 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4079387 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4079387 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL4087778 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4089696 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4087107 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4090681 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4099159 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4071291 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4081123 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4098329 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4098329 | — | IC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL4059908 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4059908 | — | IC50 | = | 28183.83 | nM | 4.55 |
| CHEMBL4081825 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4064652 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4064652 | — | IC50 | = | 28840.32 | nM | 4.54 |
| CHEMBL408701 | TAUROLITHOCHOLIC ACID | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL4074295 | — | IC50 | = | 83000.0 | nM | 4.08 |